highcardflush|China's supercomputer aids in combating diabetic complications
GUANGZHOUhighcardflush, June 9 (Xinhua) -- Chinese scientists, leveraging one of the world's fastest supercomputers, have identified a promising therapeutic strategy for treating diabetic complications.
The Tianhe-2 supercomputer in south China's Guangdong Province, ranking 16 among the global top 500 fastest computers published last month, has been used as a platform for drug discovery.
Supported by Virtual Screening on Tianhe-2 (VSTH), a high-throughput screening platform running on Tianhe-2, the team led by researchers from Sun Yat-sen University has found that 2MBC, a branched-chain acylcarnitine, can significantly speed up the rate of blood clot formation in the body.
Diabetes ranks among the most prevalent chronic conditions worldwide. It has the potential to trigger a cascade of complications including blood clot formation, a leading contributor to both disability and mortality within the diabetic population.
The researchers have found that 2MBC exerts a direct influence on platelets, augmenting their capabilities for aggregation, spreading, and contraction, and the effect is present in both rodents and human.
The chemical is a metabolite originating from the gut microbiota, and therefore, pre-treatment with antibiotics to clear the gut bacteria effectively halts this metabolic conversion, according the study published recently in the journal Cell Metabolism.
This discovery paves the way for novel therapeutic targets and innovative strategies in combating complications associated with metabolic disorders like diabetes, said the researchers.
Also, the Tianhe-2 team has vowed to enhance the drug discovery platform, capitalizing on the rich data resources and the platform's superior performance to catalyze groundbreaking innovation in the field of biomedicine.■
Tags:
Recommendations
- dragontigergate|3 arrested over drug trafficking in S. Afghanistan
- singaporeseagamessoccer|UN chief urges global action to tackle extreme heat
- kinggamescandycrush|Feature: Interactive symphony by Chinese American enlivens music scene in NYC
- badugirules|Singapore's Changi Airport records 13.4 pct growth in passenger movements in Q2
- popeyevideogame|Various sectors in Vietnam pay respect to late party chief Nguyen Phu Trong
- Tiger'sTroveTrail|View of Nanhua Mountain in China's Ningxia
- baccarist|Internet celebrities from 21 countries visit Shanghai
- gamblingsitesfreespins|Summer scenery of Sanya, S China
- buzzbingofreespins|Shanghai metro introduces luggage storage self-service for hassle-free travel
- crashbandicootnintendo64|China to cut gasoline, diesel retail prices